Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-11-07
1999-01-19
Prouty, Rebecca E.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 435 691, 435189, 4352523, 4353201, C12N 1553, C12N 902, C12N 1563, C12N 1570
Patent
active
058614966
ABSTRACT:
The present invention provides a human squalene epoxidase (HSQEP) and polynucleotides which identify and encode HSQEP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSQEP and a method for producing HSQEP. The invention also provides for the use of HSQEP and agonists, antibodies, or antagonists specifically binding HSQEP, in the prevention and treatment of diseases associated with expression of HSQEP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSQEP for the treatment of diseases associated with the expression of HSQEP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSQEP.
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Hawkins Phillip R.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Moore William W.
Prouty Rebecca E.
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