Peptide lung surfactants and therapeutic combinations

Details Peptide lung surfactants and therapeutic combinations Peptide lung surfactants and therapeutic combinations

1997-05-08

1999-01-19

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530402, 514 18, A61K 3800, C07K 500, C07K 700

Patent

active

058614818

ABSTRACT:
Synthetic pulmonary surfactant consisting of a complex of a polypeptide of 3-4 amino acid residues having alpha-helical structure and a covalently bound long chain acyl group. The peptides are useful when consisting of one or more associated lipids in combination in conditions associated with respiratory distress.

REFERENCES:
patent: 4861756 (1989-08-01), Jackson
McLean, et al. Biochemica et Biophysica Acta 1167:289-295 (1993).
McLean, et al., Am. Rev. Respir Dis vol. 147:4622-465 (1993).
McLean, et al., Biochimica et Biophysica Acta 1166:31-38 (1993).
McLean, et al., Biochemistry vol. 30(1):31-37 (1991).
McLean, et al., Biochimica et Biophysica Acta 1167:289-95 (1993).
Unpublished article.
Cochrane, et al., Science, vol. 254:566-68 (1991).
Waring, et al., Peptide Research 2(5):308-313 (1989).
Travis, Am. Rev. Respir. Dis. 135:773-774 (1987).
Heffner, et al., Am. Rev. Respir. Dis 140:531-554 (1989).
McLean, et al., American Physiological Society, pp. L292-L300 (1992).
McLean, et al., Am. Rev. Respir. Dis., vol. 147:462-465 (1993).
McLean, et al., Biochimica et Biophysica Acta, 1166:31-38 (1993).
McLean, et al., Journal of Pharma. and Exp. therapeutics, vol. 266(2):551-556 (1993).
Fanger, et al., J. Cellular Biochemistry, Supplement 15B, Jan. 18-24, 1991, p. 123.
Cochrane, et al., "Pulmonary Surfactant Protein B (SP-B): Structure-Function Relationships", Science, vol. 254:566-568 (1991).
Waring, et al., "Synthetic Amphipathic Sequences of Surfactant Protein-B Mimic Several Physicochemical and In Vivo Properties of Native Pulmonary Surfactant Proteins", Peptide Research 2(5):308-313 (1989).
McLean, et al., "Role of the Hydrophobic Face of Amphipathic Alpha-Helical Peptides in Synthetic Pulmonary Surfactants", The Journal of Pharmacology and Experimental Therapeutics, vol. 266, No. 2, pp. 551-266 (1993).
Travis, Am. Rev. Respir. Dis. 135:773-774 (1987).
Heffner, et al., Am. Rev. Respir. Dis 140:531-554 (1989).
McLean, et al., American Physiological Society, pp. L292-L300 (1992).

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