Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-07
2000-08-29
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241861, 4241871, 4241931, 4242781, 4242281, 435 693, 4352523, 4353201, 530324, 530325, 530 26, 530327, 530328, 530329, A61K 3929
Patent
active
061104655
ABSTRACT:
The nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of 49 isolates of hepatitis C are disclosed. The invention relates to the use of these sequences to design proteins and nucleic acid sequences useful in diagnostic methods and vaccines.
REFERENCES:
Choo, et al., "Vaccination of chimpanzees against infection by the hepatitis C virus," Proc. Natl. Acad. Sci. USA, (1994) 91:1294-1298.
Bukh, J., et al., "Sequence analysis of the core gene of 14 hepatitis C virus genotypes," Proc. Natl. Acad. Sci. USA, (1994) 91:8239-8243.
Bukh, J., et al., "At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide," Proc. Natl. Acad. Sci., (1993) 90:8234-8238.
Farci, P. et al., "Lack of Protective Immunity Against Reinfection with Hepatitis C Virus," Science (1992) 258:135-140.
Prince, et al., "Immunity in Hepatitis C Infection," J. Infect. Dis., (1992) 165:438-443.
Letvin, N.L., et al., "Vaccines Against Human Immunodeficiency Virus--Progress and Prospects," N. Engl. J. Med., (1993) 329:1400.
Zibert, A., et al., "Antibodies in Human Sera Specific to Hypervariable Region 1 of Hepatitis C Virus Can Block Viral Attachment," Virology, (1995) 208:653-661.
Bukh, J., et al., "Genetic Heterogeneity of Hepatitis C Virus: Quasispecies and Genotypes," Seminar in Liver Disease (1995) 15:1, 41-63.
Farci, P., et al., "Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization," Proc. Natl. Acad. Sci., (1994) 91:7792-7796.
Shimuzu, Y. K., et al., "Neutralizing Antibodies against Hepatitis C Virus and the Emergence of Neutralization Escape Mutant Viruses," J. Virol., (1994) 68:1494-1500.
Chayama, K. et al., Nucleotide sequence of hepatatis C virus (type 3b) isolated from a Japanese patient with chronic hepatitis C, Journal of General Virology, (1994) 75:3623-3628.
Bukh Jens
Miller Roger H.
Purcell Robert H.
Scheiner Laurie
The United States of America as represented by the Department of
LandOfFree
Nucleotide and deduced amino acid sequences of hypervariable reg does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleotide and deduced amino acid sequences of hypervariable reg, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleotide and deduced amino acid sequences of hypervariable reg will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1246732