Synthetically derived peptide

Details Synthetically derived peptide Synthetically derived peptide

1993-03-15

1999-01-19

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3800, C07K 500, C07K 700

Patent

active

058613765

ABSTRACT:
A peptide (QSP-9124) was synthesized corresponding to the 34 residue sequence of a peptide precursor to the bacteriocin LL-2 produced by Lactococcus lactis LLA-2.0. The precursor to native bacteriocin LL-2 is extensively modified by post-translational mechanisms. Serine and threonine residues are dehydrated and lanthionine and methyl-lanthionine sulfur bridges are formed between cysteine and several of the dehydrated serine and threonine residues. The synthesized peptide has greater anti-bacterial action against Listeria monocytogenes, than did the native, post-translationally modified protein LL-2. Antibacterial activity against several beneficial food lactobacterial strains was absent, so that the peptide is of value as a food preservative against L. monocytogenes.

REFERENCES:
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