Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1998-04-03
2000-08-29
Bockelman, Mark
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 20, A61N 130
Patent
active
061101613
ABSTRACT:
A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The pharmaceutical drug or nucleic acid is first injected into the muscle at one or multiple sites. Immediately, or shortly after, injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the pharmaceutical drug or nucleic acid to enter the cell. The efficiency of transfer permits robust immune responses using DNA vaccines and produces sufficient secreted proteins for systemic biological activity to be observed.
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Lomo Terje
Mathiesen Iacob
Bockelman Mark
Electrofect AS
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