X-ray or gamma ray systems or devices – Specific application – Computerized tomography
Patent
1996-05-15
1997-11-11
Porta, David P.
X-ray or gamma ray systems or devices
Specific application
Computerized tomography
378901, 36441315, A61B 603
Patent
active
056872089
ABSTRACT:
A method and apparatus are disclosed for predicting prior to injection an organ specific contrast enhancement in a patient for a preselected contrast injection protocol for pre-determining a computed tomography scan. The invention is preferably implemented in a computer program which creates a mathematical model of human cardiovascular physiology in a hypothetical patient with a specific body habitus subjected to the pre-selected contrast injection protocol. The predicted contrast enhancement is then displayed for operator approval and may be then used to control a CT scanner or contrast injector system, to perform the injection and scan with the pre-selected injection protocol and scan parameters. The mathematical model includes models of organs and vessels using differential equations to describe mass transport of contrast agent through the cardiovascular system. Also disclosed are a method and apparatus for predicting optimum injection protocol for contrast agent by analyzing the predicted enhancement levels and updating the injection protocol until acceptable enhancement levels are predicted as well as a method and apparatus for determining an optimum scan interval when enhancement levels are predicted to exceed a threshold level for a time period greater than the scan duration. Further disclosed is a method and apparatus for monitoring a region of interest in the patient different from the region to be scanned after injection to calibrate the mathematical model and more accurately predict enhancement levels in the tissue to be scanned and calculate the optimum scan parameters.
REFERENCES:
patent: 5301672 (1994-04-01), Kalender
patent: 5459769 (1995-10-01), Brown
patent: 5583902 (1996-12-01), Bae
Lars Kopka, M.D., et al., Dual-phase Helical CT of the Liver: Effects of Bolus Tracking and Different Volumes of Contrast Material, Radiology vol. 201, No. 2, Nov. 1996, pp. 321-326.
Dynamic Hepatic CT: How Many Years Will It Take 'Til We Learn? Walkey, MM. Radiology vol. 1, Oct., 1991: 181:17-24.
Investigation of Contrast Enhancement In CT Of The Liver: The Need For Improved Methods, Dodd, GD, Baron, TL. (commentary). AJR 1993: 160:643-646.
Contrast-Enhanced Spiral CT Of The Liver: Effect Of Different Amounts And Injection Rates Of Contrast Material On Early Contrast Enhancement. Small, WC, Nelson, RC, Bernadino, ME, Brummer, LT. AJR 1994: 163-87-92.
Cardiac Output And Regional Blood Flow, Wade OL, Bishop, JM. F.A. Davis Co., Philadelphia, 1962, pp. 86-95.
Cardiovascular Physiology. Milnor, WR. Oxford University Press, Oxford, 1990, pp. 6-13; 28-39; 52-59; 328-331; 436-445.
Structure-Function Relations In The Peripheral Circulation; Best & Taylor's Physiological Basis of Medical Practice; Twelfth Edition; Chapter 6, pp. 118-123; 128-130; and 142; Chapter 25; Physiology Of The Body Fluids, pp. 406-408, edit by West, JB., Williams & Wilkins, 1991.
Circulation-Time Models Of The Uptake Of Inhaled Anaesthetics And Data For Quantifying Them. Mapleson, WW. Brit J. Anaesth, 1973; 45:319-333.
Summary of Organ Weight (g) For Pediatric And Adult Phantoms, CRC Handbook of Medical Physics. ICRP Publication 23, 1984. pp. 428, 134-135.
Local Control of Blood Flow by the Tissues and Nervous and Humoral Regulation, Textbook of Medical Physiology, Chapter 20. Guyton, AC. WB Saunders Co. 7th Ed. Philadelphia, 1986. pp. 228, 230, 340, 342, Chapter 33, Partition of The Body Fluids: Osmotic Equilibria Between Exctracellular And Intracellular Fluids, pp. 382, 384, 386, 388, 390, and 392.
Human Pharmacokinetics Of Iohexol: A New Nonionic Contrast Medium. Olsson B, Aulie A, Sveen K, Andrew E; Investigative Radiology Mar.-Apr. 1983; vol. 18, 18:177-182.
Applications Of A Mathematical Model For Drug Distribution In Mammals In Chemical Engineering In Medicine And Biology. Bischoff, KB. Edited by D. Hershey, Plenum Press, NY, 1967; 417-466.
Transport Phenomena in the Cardiovascular System, Middleman, S. John Wiley & Sons, Inc. NY, 1972, pp. 1-299.
Radioisotopes and Circulation. Nadler SB, Hidalgo JU. Little, Brown& Co., Blood Volume. Ch. 4, Boston 1965, pp. 64-71, 86-93.
Numerical Recipes. Chapter 15, Integration of Ordinary Differential Equations. Press WH, Flannery BP, Teukolsy SA, Vetterling WT, Cambridge University Press, Cambridge, 1986. pp. 547-561.
Dynamic Contrast-Enhanced CT of the Liver: Comparison of Contrast Medium Injection Rates and Uniphasic and Biphasic Injection Protocols. Heiken JP, Brink JA, McClennan BL, Sagel SS, Forman HP, DiCroce J. Radiology May, 1993; 187:327-331.
Dynamic Incremental CT: Effect of Volume and Concentration of Contrast Material and Patient Weight on Hepatic Enhancement. Heiken JP, Brink JA, McClennan BL, Sagel SS, Crowe TM, Gaines MV. Radiolgoy May, 1995; 195:353-357.
Extravascular Contrast Material: The Major Component of Contrast Enhancement. Kormano M, Dean PB. Radiology Nov., 1976; 121:379-382.
The Permeability of Capillaries in Various Organs as Determined by Use of The `Indicator Diffusion` Method. Crone, C. Acta Physiol Scand 1963; 58:292-305.
Estimation of The Capillary Permeability Coefficients of Inulin in Various Tissues of the Rabbit. Wittmers LE, Bartlett M., Johnson JA. Microvas Res 1976; 11:67-78.
A Linear Method for Determining Liver Sinusoidal and Extravascular Volumes. Goresky CA. American Journal Physiology 1963; 204(4):626-640.
Capillary Exchange Modeling: Barrier-Limited and Flow-Limited Distribution. Goresky CA. Ziegler WH, Bach GG. Circulation Research Nov., 1970; 27:739-764.
Some Mathematical Aspects Of Chemotherapy-II: The Distribution of a Drug in the Body. Bellman R., Jacquez JA, Kalaba R. Bull Math Biophys. 1960; 22:309-322.
Respiration and Circulation; Altman PL, Ditmer DS; Federation of American Society of Experimental Biology; Bethesda, MD 1971, pp. 227, 232, 234, 320, 357, 377, 379, 383, 385, 417, 419, 424, 426, 428, 431, 433, 435, 459, 501, 503, 505, 507, 510.
Radiopapque Contrast Media Radiopharmaceuticals Enhancement Agents for Magnetic Resonance Imaging and Ultrasound; Swanson DP, Weingarden M, Swanson DP, Chilton HM, Thrall JH, ed. Pharmaceuticals in Medical Imaging; Macmillan Pub. Co. NY, 1990, pp. 78-97.
Circulatory Physiology: Cardiac Output and its Regulation; Guyton AC, WB Saunders Co., Philadelphia, 1963, pp. 3-15, 154-157.
Changes in Cardiac Output With Age; Brandfonbrener M. et al.; Circulation vol. 12; Oct., 1995, pp. 557-566.
Measurement of Cardiac Output by Computed Transmission of Tomography; Herfkens RJ, et al.; Inv. Radiology Nov-Dec., 1982, pp. 550-553.
Dynamic Contrast Enhancement of the Upper Abdomen: Effect of Contrast Medium and Body Weight; Kormano, M, M.D., Kaarina P., M.D., Soimakallio, S., M.D., Kivimaki, T., RT. Investigative Radiology, vol. 18, Jul.-Aug. 1983, pp. 364-367.
Helical CT of the Liver: Clinical Application of an Automated Computer Technique SmartPrep for Obtaining Images With Optimal Contrast Enhancement; Silverman P., Roberts S., Tefft MC., Brown B., Fox SH., Cooper C., Zeman R. AJR, Jul., 1995 165:73-78.
Optimal Contrasst Enhancement of the Liver Using Helical (Spiral) CT: Value of SmartPrep; Silverman P., Brown B., Wray H., Fox S., Cooper C., Roberts S., Zeman R.; AJR May, 1995; 164:1169-1171.
Technical Developments and Instrumentation. Parenchymal Liver Enhancement With Bolus-Triggered Helical CT: Preliminary Clinical Results; Kopka L., Funke M., Fischer U., Vosshenrich R., Oestmann JW., Grabbe E. Radiology Apr., 1995, vol. 195, No. 1, pp. 282-284.
Application of Pharmacokinetics to Computed Tomography Injection Rates and Schemes: Mono-, Bi-, or Multiphasic; Werner Kraus, PhD.; Investigative Radiology, Feb. 1996, vol. 31, pp. 91-100.
Fundamentals of Special Radiographic Procedures; Albert M. Snopek; Third Edition, Automatic Injection Devices; Chapter 3, pp. 38-65.
Fundamentals of Angiography, Tortorici M.; 1982, Automatic Injectors; Chapter 5, pp. 69-80.
Assessment of a Technology That Permits Individualized Scan Delays on Helical Hepatic CT: a Technique to Improve Efficiency in Use of Contrast Material, Silverman, P., et al.; AJR:167, Jul. 1996, pp. 79-84.
Helical CT of the liver: Evaluati
Bae Kyongtae T.
Brink James A.
Heiken Jay P.
BHB General Partnership
Bruce David Vernon
Porta David P.
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