Recombinant DNA encoding Human peroxisome proliferator activated

Details Recombinant DNA encoding Human peroxisome proliferator activated Recombinant DNA encoding Human peroxisome proliferator activated

1995-06-02

1997-11-11

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, 530350, C12P 2106, C07K 100, C07K 1700

Patent

active

056865961

ABSTRACT:
A human peroxisome proliferation activated receptor gene is purified from the environment in which it naturally occurs, and preferably provided within an expression vector.

REFERENCES:
Havel and Kane, "Drugs and Lipid Metabolism," Ann. Rev. Pharmac. 13:287-308 (1973).
Green, "Receptor-Mediated Mechanisms of Peroxisome Proliferators," Biochemical Pharmacology 43:393-401 (1992).
Issemann and Green, "Activation of a Member of the Steroid Hormone Receptor Superfamily by Peroxisome Proliferators," Nature 347:645-650 (1990).
Gottlicher et al., "Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor," Proc. Natl. Acad. Sci. USA 89:4653-4657 (1992).
Dreyer et al., "Control of the Peroxisomal .beta.-Oxidation Pathway by a Novel Family of Nuclear Hormone Receptors," Cell 68:879-887 (1992).
Schmidt et al, "Identification of a New Member of the Steroid Hormone Receptor Superfamily That Is Activated by a Peroxisome Proliferator and Fatty Acids," Molecular Endocrinology 6:1634-1641 (1992).
Sher et al., "cDNA Cloning, Chromosomal Mapping, and Functional Characterization of the Human Peroxisome Proliferation Activated Receptor," Biochemistry 32: 5598-5604 (1993).

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