Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1975-05-01
1977-08-09
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 12, 424 7, G01N 3300, G01N 3316, A61K 4300
Patent
active
040411460
ABSTRACT:
A monomolecular layer of first biological particles is absorbed on the surface of a non-reactive substrate. The coated substrate is exposed to a solution suspected of containing second biological particles specific to the first biological particles. Next, the coated substrate is subjected to a tagging step, following which it is exposed to a cleaving agent solution which cleaves the bond between the first and second biological particles. The used cleaving agent solution is then examined by a tag-sensing instrument following possible concentration thereof for determining whether tag-bearing second particles have been removed. The tags may, for example, be radioactive, fluorescent, etc. A supplement is described, wherein the coated substrate is studied with a tag-sensing instrument before and after exposure of the coated substrate to the cleaving agent solution to help provide said determination.
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Chidlow et al, Biochem. Journal (Great Britian), vol. 117, 1970, pp. 49-55.
Cohen Joseph T.
General Electric Company
MaLossi Leo I.
Nucker Christine M.
Padgett Benjamin R.
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