Bioconversion of a fermentable carbon source to 1,3-propanediol

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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43525231, 43525233, C12P 718, C12N 1500, C12N 988, C12N 119

Patent

active

056862768

ABSTRACT:
A process is provided for the bioconversion of a carbon substrate to 1,3-propanediol by a single organism utilizing either microorganisms containing the genes encoding for an active glycerol or diol dehydratase enzyme by contacting these organisms with a carbon substrate under the appropriate fermentation conditions.

REFERENCES:
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Tobimatsu, T. et al, J. Biolog. Chem., 270(13), 7142-7148 (1995).
Sobolov, M. et al, J. of Bacteriology, 79, 261-266 (1993).
Talarico, T.L. et al., Applied and Environmental Microbiology, Apr. 1990, pp. 943-948.
Chemical Abstracts, vol. 118, No. 7, 15 Feb. 1993, Daniel, Rolf et al., "Growth Temperature-Dependent Activity of Glycerol Dehydratase in Escherichia coli Expressing the Citrobacter Freundii dha Regulon".
Chemical Abstracts, vol. 116, No. 9, 2 Mar. 1992, Tong, I Teh et al., "1,3-Propanediol Production by Escherichia coli Expressing Genes from the Klebsiella pneumoniae dha Regulon".
Chemical Abstracts, vol. 120, No. 11, 14 Mar. 1994, Otto, Karin Elizabeth, "Cloning and Characterization of the Propanediol Dehydratase Genes in Salmonella typhimurium".
Chemical Abstracts, vol. 118, No. 17, 26 Apr. 1993, Boenigk, Rainer et al., "Fermentation of Glycerol to 1,3-Propanediol in Continuous Cultures of Citrobacter freundii".

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