Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-08-02
1997-11-11
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 436536, 436547, 5303898, 546122, G01N 3353, C07D47104, C07K 1600
Patent
active
056862512
ABSTRACT:
The present invention provides naphthyridinium derivatives which are effective, for example, in diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. and also provides an antibody prepared from said derivative as a hapten. The naphthyridinium derivatives of the present invention are compounds represented by the general formula (I): ##STR1## wherein R and R' may be the same or different and are alkyl groups optionally substituted with at least one amino group, at least one protected amino group, at least one carboxyl group, or combinations thereof, and their pharmaceutically accepted salts. It is possible to conduct the diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. using a compound of the present invention as an indicator. Moreover, it is possible to utilize a compound of the present invention for the evaluation of the pharmaceutical effect of pharmaceuticals effective for treating diabetes-related diseases, dialysis-related complications, aging and diseases accompanied by aging.
REFERENCES:
patent: 5338850 (1994-08-01), Nakamura et al.
Sensi, et al., "Advanced Nonenzymatic Glycation Endproducts (Age): Their Relevance To Aging And The Pathogenesis Of Late Diabetic Complications", Diabetes Research (1991) 16, 1-9.
Brownlee, M., "Glycation Products and the Pathogenesis of Diabetic Complications", Diabetes Care, vol. 15, No. 12, Dec. 1992, pp. 1835-1843.
Brownlee, et al., "Advanced Glycosylation End Products In Tissue And The Biochemical Basis Of Diabetic Complications", The New England Journal of Medicine, vol. 318, No. 20, 1315-1321.
Lyons, "Glycation and Oxidation: A Role in the Pathogenesis of Atherosclerosis", The American Journal of Cardiology, vol. 71, Feb. 25, 1993, pp. 26B-31B.
Harrington, et al., "A glycation connection", Nature, vol. 370, 28 Jul. 1994, pp. 247-248.
Yan, et al., "Non-enxymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid .beta.-peptide", Nature Medicine, vol. 1, No. 7, Jul. 1995, pp. 693-699.
Lamb, et al., "Serum Glycated Albumin and Fructosamine in Renal Dialysis Patients", Nephron, 1993; 64:82-88.
Lamb, et al., "Glycated albumin in serum and dialysate of patients on continuous ambulatory peritoneal dialysis", Clinical Science (1993) 84, 619-626.
Huber, et al., "Formation of 2-(2-furoyl)-4(5)-(2-furyl)-1H-imidazole in the Maillard Reaction", Carbohydrate Research, vol. 182, No. 2, pp. 301-306.
Nakamura, et al., "Crosslines A and B as Candidates for the Fluorophores in Age- and Diabetes-related Cross-linked Proteins, and their Diacetates produced by Maillard Reaction of .alpha.-N-Acetyl-L-lysine with o-Glucose", J. Chem. Soc. Chem. Commun., 1992, pp. 992-994.
Horiuchi Seikoh
Ienaga Kazuharu
Nakamura Ko
Achutamurthy Ponnathapura
Nippon Zoki Pharmaceutical Co. Ltd.
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