Determination of oligonucleotides for therapeutics, diagnostics

Details Determination of oligonucleotides for therapeutics, diagnostics Determination of oligonucleotides for therapeutics, diagnostics

1994-10-27

1997-11-11

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 536 231, 536 253, C12Q 168, G01N 3353, C07H 2100

Patent

active

056862423

ABSTRACT:
Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against said biomolecules, followed by recovery and characterization of selected oligonucleotides. Oligonucleotides so determined may be utilized for therapeutic, diagnostic and research reagent purposes.

REFERENCES:
patent: 4935357 (1990-06-01), Szybalski
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5475096 (1995-12-01), Gold et al.
Frohman et al. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA vol. 85 pp. 8998-9002 1988.
Promega Catalog 1993/1994 p. 58 1993.
Brenowitz et al. Quantitative DNase fpptprint titration: A method for studying protein-DNA interactions Methods in Enzymology vol. 130 132-181 1986.
Tullius et al. Hydroxy radical footprinting: A high-resolution method for mapping protein-DNA contacts Methods in Enzymology vol. 155 537-558 1987.
Hasegawa et al. Genomic divergence of HIV-2 from Ghana AIDS Research and Human Retroviruses vol. 5 593-604 1989.
Sekiya et al. Molecular cloning and the total nucleotide sequence of the heman c-Ha-ras-1 gene activated in a melanoma from a Japanese patient Proc. Natl. Acad. Sci. USA vol. 81 4771-4775 1984.
Kato et al. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis Proc. Natl. Acad. Sci. USA vol. 87 9524-9528 1990.
Musso et al. Construction and characterization of versatile kanamycin-resistance cassettes derived from the Tn5 transposon Gene vol. 85 205-207 1989.
Xu et al. The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated withthe 5' portion of the U4 small nuclear RNA Molecualr and Cellular Biology vol. 10 1217-1225 1990.
Blackwell et al., "Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection", Science 250: 1104-1110 (1990).
Blackwell et al., "Sequence-Specific DNA Binding by the c-Myc Protein", Science 250: 1149-1151 (1990).
Bock et al., "Selection of Single-Stranded DNA Molecules that Bind and Inhibit Human Thrombin", Nature 355:564-566 (1992).
Carchon et al., "Capillary electrophoresis", Amer. Biotech. Lab. 1992, 67-72.
Chittenden et al., "The T/E1A-Binding Domain of the Retinoglastoma Product Can Interact Selectively with a Sequence-Specific DNA-Binding Protien", Cell 65:1073-1082 (1991).
Cobb and Novotny, "Peptide Mapping of Complex proteins at the Low-Picomole Level with Capillary Electrophoretic Separations" Anal. Chem. 64: 879-886 (1992).
Dooley and Houghten, "The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries for the Rapid Determination of Opioid Receptor Ligands" Life Sciences, 1993, 52, 1509-1517.
Dooley, et al., "Acetalins: Opioid Receptor Antagonists Determined Through the Use of Synthetic Peptide Combinatorial Libraries" Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 10811-10815.
Dvoretzky et al., "A Quantitative in Vitro Focus Assay for Bovine Papilloma Virus" Virology 103: 369-375 (1980).
Ellington & Szostak, "In Vitro Selection of RNA Molecules That Bind Specific Ligands" Nature 346: 818-822 (1990).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis" Science 251: 767-773 (1991).
Geysen et al., "A Priori Delineation of A Peptide Which Mimics a Discontinuous Antigenic Determinant" Molec. Immunology 23: 709-715 (1986).
Gorman et al., "Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells" Molec. & Cellular Biology 2: 1044-1051 (1982).
Graham and Van Der Eb, "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA" Virology 52: 456-467 (1973).
Groger et al., "Directional Antisense and Sense cDNA Cloning Using Epstein-Barr Virus Episomal Expression Vectors" Gene 81: 285-294 (1989).
Houghten et al., "Generation and Use of Synthetic Peptide Combinatorial Libraries for Basis Research and Drug Discovery" Nature 354: 84-86 (1991).
Henderson et al., "HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation" Science 1992 255 1264-1266.
Hunt, et al., "Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry" Science, 1992, 255, 1261-1263.
Jayawickreme, Channa et al., "Creation and Functional Screening of a Multi-use Peptide Library" Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 1614-1618.
Jellinek, D. et al., "High-Affinity RNA Ligands to Basic Fibroblast Growth Factor Inhibit Receptor Binding" Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 11227-11231.
Jenison, Robert D. et al., "High-Resolution Molecular Discrimination by RNA" Science, 1994, 263, 1425-1429.
Joyce, "Amplification, Mutation and Selection of Catalytic RNA" Gene 82: 83-87 (1989).
Kinzler and Vogelstein, "Whole Genome PCR: Application to the Identification of Sequences Bound by Gene Regulatory Proteins", Nucleic Acids Res. 17: 3645-3653 (1989).
Kinzler and Vogelstein, "The GLI Gene Encodes a Nuclear Protein Which Binds Specific Sequences in the Human Genome" Molecular and Cellular Biology 10: 634-642 (1990).
Lam et al., "A New Type of Synthetic Peptide Library for Identifying Ligand-Binding Activity" Nature 354: 82-84 (1991).
Ohlmeyer et al., "Complex Synthetic Chemical Libraries Indexed with Molecular Tags" Proc. Natl. Acad. Sci. USA 90: 10922-10926 (1993).
Owens et al., "The Rapid Identification of HIV Protease Inhibitors Through the Synthesis and Screening of Defined Peptide Mixtures", Biochem & Biophys. Res. 181: 402-408 (1991).
Robertson and Joyce, "Selection in vitro of an RNA Enzyme That Specifically Cleaves Single-Stranded DNA" Nature 344 467-8 Mar. 29, 1990.
Rodriguez et al., "Capillary non-gel sieving electrophoresis of nucleic acids", Amer. Biotech. Lab. 1992, 21-22.
Schneider, Dan et al., "Selective Enrichment of RNA Species for Tight Binding to Escherichia coli rho Factor" FASEB J., 1993, 7, 201-207.
Schneider, Dan et al., "Selection of High Affinity RNA Ligands to the Bacteriophage R17 Coat Protein" J. Mol. Biol., 1992, 228, 862-869.
Stevenson, "HPCE '92: Will this kid amount to much?" Amer. Lab, 1992, 17-22.
Thiesen and Bach, "Target Detection Assay (TDA): A Versatile Procedure to Determine DNA Binding Sites as Demonstrated on SP1 Protein", Nuc. Acids Res 18: 3203-3209 (1990).
Toulas et al., "Applications of a Laser-Induced Fluorescence Detector for Capillary Electrophoresis to Measure Attomolar and Zeptomolar Amounts of Compounds" LC-GC, 1992, 10, 471-476.
Tuerk and Gold, "Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase", Science 249: 505-510 (1990).
Zuckerman, Ronald N. et al., "Identification of Highest-Affinity Ligands by Affinity Selection from Equimolar Peptide Mixtures Generated by Robotic Synthesis" Proc. Natl. Acad. Sci. 1992, 89, 4505-4509.
Krieger et al., "Capillary electrophoresis" Chem. and Engin. News, 1992, 69-70.

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