Methods and polycyclic aromatic compound containing compositions

Details Methods and polycyclic aromatic compound containing compositions Methods and polycyclic aromatic compound containing compositions

1993-03-30

1996-05-07

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514569, 514680, 514885, A61K 31195, A61K 3119, A61K 3112

Patent

active

055147143

ABSTRACT:
T cell-mediated diseases in mammals are treated using compositions comprising a polycyclic aromatic compound, preferably hypericin or pseudohypericin, and related compounds, including isomers, analogs, derivatives, salts, or ion pairs of hypericin or pseudohypericin. The above composition may be administered in combination with an immunosuppressive agent. Pharmaceutical compositions useful for treating a T cell-mediated disease comprise the above polycyclic aromatic compound, alone or in combination with an immunosuppressive agent. The compositions and methods are useful in treating diseases which include multiple sclerosis, myasthenia gravis, scleroderma, polymyositis, graft-versus-host disease, graft rejection, Graves disease, Addison's disease, autoimmune uveoretinitis, autoimmune thyroiditis, pemphigus vulgaris and rheumatoid arthritis. Psoriasis and systemic lups erythematosus. Also provided are methods for diminishing the expression of CD4 Molecules on the surface of a T lymphocyte, and for inducing multidrug resistance in a cell, comprising incubating the cell with an effective concentration of a polycyclic aromatic compound.

REFERENCES:
patent: 4898891 (1990-02-01), Lavie et al.
Meruelo et al, "Therapeutic Agents With . . . Pseudohypericin" Proc. Nat. Acad Sci., U.S.A., vol. 85, pp. 5230-5234, Jul. 1988.
The Merck Manual; Merck & Co Inc., Fourteenth Editon pp. 1214, 1354 (1982).

Affiliated with

Also associated with

Rating

Methods and polycyclic aromatic compound containing compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and polycyclic aromatic compound containing compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and polycyclic aromatic compound containing compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1227663