Hydroxamic acid based collagenase inhibitors

Details Hydroxamic acid based collagenase inhibitors Hydroxamic acid based collagenase inhibitors

1994-04-18

1996-05-07

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514317, 514357, 514394, 514400, 514427, 514428, 514616, 544168, 5483097, 5483381, 548561, 548571, 564153, 546233, 546337, C07C25906, A61K 3113

Patent

active

055146775

ABSTRACT:
Compounds of general formula I: ##STR1## wherein: A represents the group --NH.sub.2, a substituted acyclic amine or a heterocyclic base;
have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumour invasion.

REFERENCES:
patent: 4105789 (1978-08-01), Ondetti et al.
patent: 4496540 (1985-01-01), Kim
patent: 4599361 (1986-07-01), Dickens et al.
patent: 4738803 (1988-04-01), Roques
patent: 5304604 (1984-04-01), Davidson
Woolley et al, Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint, Arthritis and Rheumatism, vol. 20, No. 6, 1231-1239 (1977).
Cawston et al., A Rapid and Reproducible Assay for Collagenase Using 1-.sup.14 C!Acetylated Collagen, Analytical Biochemistry, vol. 99, 340-345 (1979).
Cawston et al, Purification of rabbit bone inhibitor of collagenase, Biochem. J., vol. 195, 159-165 (1981).
Cawston et al, Mammalian Collagenases, Methods in Enzymology, vol. 80, 781 (1981).
Hayward et al, The Effect of Reversal of the Direction of Peptide Bonds on the Interaction Between Peptide Hormones and Receptors, Pept. Proc. Eur. Pept. Symp. 13th, 287-298 (1974, published 1975).
Amomoto et al, Microbiol. Immunol. 28 85 (1984) Abstact Only.

Affiliated with

Also associated with

Rating

Hydroxamic acid based collagenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydroxamic acid based collagenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydroxamic acid based collagenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1227383