Method and agents for raising animal tolerance to oxidant stress

Details Method and agents for raising animal tolerance to oxidant stress Method and agents for raising animal tolerance to oxidant stress

1983-05-25

1985-10-22

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514222, 514223, A61K 3171

Patent

active

045489270

ABSTRACT:
A method and agents are disclosed for raising the tolerance of animal tissue to antibiotic compounds that induce oxidant stress. The method comprises administering one or more nontoxic redox compounds to the locus of administration of the antibiotic in an amount sufficient to diminish the production of the potentially toxic oxidants. The redox compounds may be administered by various parenteral techniques. The agents comprise redox compounds and include redox dyes such as those of the thiazine group. Of this group methylene blue is preferred. A method for treating cancer in animals is also disclosed.

REFERENCES:
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patent: 3876783 (1975-04-01), Gavrilescu et al.
patent: 4170640 (1979-10-01), Grigg et al.
patent: 4225588 (1980-09-01), Grigg et al.
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Chemical Abstracts; vol. 92, (1980), Burrows, 35307g.
Merck Index; 8th Edition (1968); "Methylene Blue".
G. W. Grigg et al., "Amplification of Phleomycin and Bleomycin-Induced Antibiotic Activity in E. Coli etc.", Jour. Antibiotics, vol. XXX, No. 10, pp. 870-888, (Oct. 1977).
A. D. Wolfe et al., "Labilizing Action of Intercalating Drugs and Dyes on Bacterial Ribosomes", Biochemistry, vol. 11, No. 9, pp. 1549-1572, Table I, (Apr. 25, 1972).
W. Krivit, "Hematological Aspects of Vitamin E Adriamycin Cardiotoxicity Amelioration by .alpha.-Tocopherol", Chemical Abstracts, vol. 93, No. 5, p. 1, Abstract No. 36500x (Aug. 4, 1980).

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