Process for the preparation of 4-amino-.DELTA.4-3-ketosteroids v

Details Process for the preparation of 4-amino-.DELTA.4-3-ketosteroids v Process for the preparation of 4-amino-.DELTA.4-3-ketosteroids v

1999-02-24

1999-11-23

Dodson, Shelley A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552522, C07J 4100

Patent

active

059903287

ABSTRACT:
The present invention provides 4-nitro-.DELTA..sup.4 -3-ketosteroids, their use as steroid C.sub.17-20 lyase and 5.alpha.-reductase inhibitors and to a novel process for preparing a compound of the formula: ##STR1## comprising sequentially: a) reacting a starting compound of the formula ##STR2## with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitrosteroid; and then;

REFERENCES:
Ekhato et al, Synthesis of new nitro and amino sterols, J. Chem. Soc., Perkin Trans. 1, vol. 12, 3239-42, 1988.

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