Tetrazole derivatives of bile acids, and their use as lipid leve

Details Tetrazole derivatives of bile acids, and their use as lipid leve Tetrazole derivatives of bile acids, and their use as lipid leve

1994-05-05

1995-11-14

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548253, 548112, C07D25706, A61K 3141

Patent

active

054668158

ABSTRACT:
The invention relates to tetrazole derivatives of bile acids, processes for their preparation, and use of these compounds as medicaments and cholesterol lowering agents. The tetrazole-bile acid derivatives are of the formula G1--X--G2, where G1 is H, a bile acid radical, or a bile acid radical which is modified on the hydroxyl functions and/or on the carboxyl group, X is a single bond or a bridge group between G1 and G2, and G2 is of the formula: ##STR1##

REFERENCES:
patent: 5250524 (1993-10-01), Kramer et al.
"Synthesis of 24-nor-5.beta.-cholan-23-oic acid derivatives: a convenient and efficient one-carbon degradation of the side chain of natural bile acids", Schteingart et al., Journal of Lipid Research, 29:1387-1395 (1988).
"Synthesis of Mosesin-4, a Naturally Occurring Steroid Saponin with Shark Repellent Activity, and Its Analog 7-.beta.-Galactosyl Ethyl Cholate", Gargiulo et al., Tetrahedron, 45(17):5423-5432 (1989).
"Angiotensin II receptor binding inhibitors", Hodges et al., Drugs of the Future, 17(7):575-593 (1992).

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