2-chloropentostatin compound having adenosine diaminase inhibito

Details 2-chloropentostatin compound having adenosine diaminase inhibito 2-chloropentostatin compound having adenosine diaminase inhibito

1985-11-08

1987-12-15

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 24, A61K 3170, C07H 1702

Patent

active

047133724

ABSTRACT:
2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.

REFERENCES:
patent: 3923785 (1975-12-01), Ryder et al.
patent: 3959257 (1976-05-01), Umezawa et al.
patent: 4145531 (1979-03-01), Eckstein et al.
patent: 4163839 (1979-08-01), Umezawa et al.
patent: 4195176 (1980-03-01), Baker et al.
Jackson et al., Advances in Enzyme Regulation, 25, 125-139 (1986).
Verheyden et al., Halo Sugar Nucleosides III, Reactions for the Chlorination and Bromination of Nucleoside Hydroxyl Groups, J. Org. Chem. 37(14), 2289-2299 (1972).

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