Retro-inverso analogs of the bradykinin potentiating peptide BPP

Details Retro-inverso analogs of the bradykinin potentiating peptide BPP Retro-inverso analogs of the bradykinin potentiating peptide BPP

1986-01-22

1987-12-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530314, 530323, A61K 3742, C07K 718, C07K 702

Patent

active

047133678

ABSTRACT:
New partially retro-inverso peptides of the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent, each independently, the side chain of the aminoacid residues present in the naturally occuring peptides, X is --S--Ph or --O--CH.sub.2 --Ph and Z is a hydroxy, alkoxy or amino group, are described as well as a suitable method for their preparation. The new compounds are useful as antihypertensive agents.

REFERENCES:
patent: 4522752 (1985-06-01), Sisto et al.

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