Nuclear matrix protein fluid assay

Details Nuclear matrix protein fluid assay Nuclear matrix protein fluid assay

1995-06-01

1999-11-23

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 723, 435 792, 435 794, 435961, G01N 3353, G01N 33567, G01N 33574, G01N 33531

Patent

active

059898267

ABSTRACT:
Disclosed are methods for determining the degree of cell death in a tissue by detecting and quantitating soluble interior nuclear matrix proteins and protein fragments in body fluids and extracellular media. The methods are is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of interior nuclear matrix proteins and protein fragments in soluble form from cells.

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