Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1981-12-17
1984-06-12
Turk, Arnold
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
436533, 436534, G01N 3354
Patent
active
044542330
ABSTRACT:
An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is carried by small tagged mobile units having tagging elements or compounds which are unassociated chemically with said reagent and are protected against reaction with the target and the biological and chemical environment of the assay. The tagged mobile units bearing formed complexes are measured by spectroscopic detection. Preferably the small, tagged mobile units, such as latex particles, are of a size smaller than 0.8 .mu.m. The tagged complexes which are formed may be measured by spectrophotometric detection or by mass spectrometry. Different target antigens or antibodies can be assayed simultaneously by employing different tagged mobile units, and the mobile units with the tagging elements can be recovered for disposal or for reuse.
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Turk Arnold
Wang Associates
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