Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-10-25
1999-11-23
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
530324, 530350, 435325, A61K 3900, A61K 3800
Patent
active
059895519
ABSTRACT:
The method and compositions of this invention provide an effective and reliable substitute for the currently employed ICA assay for diabetes. By providing a method for detecting autoantibodies to GAD.sub.65, IA-2 and a previously unidentified antigen termed IA-2.beta. herein, the method provides a chemical assay which has improved reliability. In addition, these antigens may be employed in therapeutic regimens aimed at achieving amelioration of the clinical condition.
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Lan Michael S.
Li Qing
Maclaren Noel K.
Notkins Abner L.
Achutamurthy Ponnathapura
Ponnaluri P.
The United States of America as represented by the Department of
The University of Florida
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