Liver function testing apparatus

Details Liver function testing apparatus Liver function testing apparatus

1990-05-21

1993-01-12

Cohen, Lee S.

Surgery

Truss

Pad

128666, 356 41, A61B 500

Patent

active

051781417

ABSTRACT:
In a liver function testing apparatus, light sources (11, 12) expose vital tissue (15) to first light of a wavelength absorbed by the specific dye dosed into blood of the vital tissue to be taken in and removed by the liver and second light of a wavelength not absorbed by the dye. Optical pulses passing through the vital tissue are received by a light receiving element (13) and first and second outputs from element (13) are sampled by an A-D converter (30) to produce respective digital signals. Pulsation components of the outputs of the receiving light are detected by high-pass filters (51, 52) and amplifiers (53, 54). A coefficient of a linear regression expression between intensity values of the pulsation components and an average value using the sampled first and second outputs of the received light are determined for performing a biocalibration. A value correlated with a specific dye concentration in the blood is calculated based on sampling outputs during a prescribed period and based on the determined average value after injection of the specific dye. Thus, a coefficient of a simulation function as a time function, is obtained by using the method of least squares and a blood plasma disappearance rate and a retention rate are obtained on the basis of the coefficient of the simulation.

REFERENCES:
patent: 3677648 (1972-07-01), Dorsch
patent: 4017192 (1977-04-01), Rosenthal
patent: 4602641 (1986-07-01), Feinberg
patent: 4905703 (1990-03-01), Kanda et al.

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