Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1995-10-06
1999-03-30
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
4242651, 4242671, 4242691, 4242221, 4242291, 424 931, 424 7816, 424 7838, 4241841, 424816, 424826, 530350, 530822, 514 2, 514561, 514567, 514649, 514773, 562562, A61K 39012, A61K 31785, A01N 3302
Patent
active
058885188
ABSTRACT:
A method for preventing and treating parasitic infections in animals by administering a lysine analog, such as EACA, to the animals on a continuous basis. In the preferred embodiment, the method of the present invention is directed to preventing and treating coccidial infections in poultry by adding EACA to the daily diet of a poultry flock. EACA may also be administered in ovo before hatching. The administration of EACA enhances the natural immune response of the poultry to the invading coccidial organisms and enables the poultry to combat the parasites without the need for antibiotics. Another aspect of the present invention involves preventing parasitic diseases in humans and animals by prophylactically administering a serine protease inhibitor, such as EACA, as an adjuvant in conjunction with a conventional vaccine effective against the target parasite.
REFERENCES:
patent: 3692904 (1972-09-01), Tsutsumi
patent: 4600582 (1986-07-01), Stevens et al.
patent: 4639372 (1987-01-01), Murray et al.
patent: 4724145 (1988-02-01), Murray et al.
patent: 4761282 (1988-08-01), Apontoweil et al.
Zhirnov et al., "Protective Effect of Protease Inhibitors in Influenza Virus Infected Animals," Archives of Virology 73, pp. 263-272 (1982).
Lozitsky et al., "Resistance of Mice to Reinfection After E-Aminocaproic Acid Treatment of Primary Influenza Virus Infection," Acta virol. 32, pp. 117-122, (1988).
Lozitsky et al, "Effectiveness of the Combined Use of an Inactivated Vaccine and a Proteolysis Inhibitor in the Prevention Of Experimental Influenza," Zh Mikrobiol Epidermiol Immunobiol (USSR) Dec. 1985 (12) pp. 49-53.
Chalyi et al., "Protease Inhibitors as Immunomodulators in Experimental Acute Pancreatitis and Staphylococcal Infection," ZH Mikrobiol Epidemiol Immunobiol (Russia), Jan.-Feb. 1993, pp. 62-65.
Hart et al., "Effect of Protease Inhibitors On Mitogen Stimulation of Hamster Lymphoid Cells," Experimental Cell Research 102 (1976), pp. 253-263.
Yee et al., "Plasminogen-Dependent Activation of Latent Transforming Growth Factor Beta (TGF.beta.) by Growing Cultures of Osteoblast-Like Cells," Journal of Cellular Physiology 157:528-534 (1993).
Puzis et al., "Action of .epsilon.-Aminocaproic Acid on the Proteolysis System During Experimental Influenza in Mice," Acta virol. 32, pp. 515-521, (1988).
Kagen et al., Dev. Biol. 1973. vol. 31, No. 2, 295-300, abstract only.
Beretich Louis D.
Beretich, Sr. Guy R.
Caputa Anthony C.
Masood Khalid
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