Cholesterol lowering compounds

Details Cholesterol lowering compounds Cholesterol lowering compounds

1992-12-07

1994-02-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562470, C07C 6976

Patent

active

052868958

ABSTRACT:
An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

REFERENCES:
patent: 3950427 (1976-04-01), Engel et al.
patent: 4171318 (1979-10-01), Chan
patent: 4736064 (1988-04-01), Baldwin
patent: 4851440 (1989-07-01), Beck et al.
Helvetica Chimica Acta, vol. 39, 1956, Habicht, E. et al., Synthesse Einiger Substituierter Citronensauren, pp. 1316-1319.
Baxter et al, Squalestatin 1, A Potent Inhibitor of Squalene Synthase Which Lowers Serum Cholesterol in Vivo, J. Biol. Chem., vol. 267, pp. 11705-11708 (1992).

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