Fluorous reaction systems

Details Fluorous reaction systems Fluorous reaction systems

1996-06-28

1998-07-07

Nazario-Gonzalez, Porfirio

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549206, 556 87, 556 88, 570241, C07F 700, C07C 1700

Patent

active

057771219

ABSTRACT:
The present invention provides a method for carrying out a chemical reaction comprising the steps of forming an organic/fluorous solubilizing liquid phase comprising a solvent system. The solvent system is selected or adapted to substantially solubilize a fluorous reaction component or components (that is, a fluorous reagent, a fluorous catalyst and/or a fluorous reactant). The "fluorous reaction component" is functionalized to comprise at least one fluorous moiety having the formula -(R).sub.d (Rf).sub.e. (Rf).sub.e is at least one fluorous group and e is a whole number. (R).sub.d is an organic (for example, hydrocarbon) spacer group, which may be present or absent, and d is an integer equal to at least zero. The solvent system is also adapted to substantially solubilize an organic reaction component or components. After the reaction occurs in the organic/fluorous solubilizing liquid phase, a phase separation into at least a fluorous phase and an organic phase is effected. The present (Rf)!.sub.3, wherein M is Ge or Sn and X is an atom or group selected to react with an organic reaction component or components.

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