AICA riboside analogs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 286, 536 287, 536 288, 514 43, 514 44, C07H 19052, A61K 3170

Patent

active

057771006

ABSTRACT:
Analogs of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) are provided which are useful in increasing extracellular levels of adenosine.

REFERENCES:
patent: 4912092 (1990-03-01), Gruber
patent: 5082829 (1992-01-01), Gruber et al.
G. Robert Greenberg, Preparation of 5'-Phosphoribosyl-5-Amino-4-Imidazolecarboxamide, J. Biol. Chem., 219:423-433, 1956.
Michael P. Groziak, et al., Nonenzymatic Synthesis of 5-Aminoimidazole Ribonucleoside And Recognition Of Its Facile Rearrangements, Proc. Natl. Acad. Sci. USA vol. 85, pp. 7174-7176, Oct. 1988.
George A. Ivanovics, et al., The Synthesis of 2-Substituted Derivatives of 5-Amino-1-.beta.-D-Ribofuranosylimidazole-4-carboxamide. Ring Opening Reactions of 2-Azapurine Nucleosies, J. Org. Chem., vol. 39, No. 25, 1974.
Kiyomi Kikugawa et al., Platelet Aggregation Inhibitors, Chem. Pharm. Bull, 25(8) pp. 1959-1969, 1977.
Ryuji Marumoto, et al., Synthesis And Coronary Vasodilating Activity Of 2-Substituted Adenosines, Chem. Pharm. Bull., 23(4), pp. 759-774, 1975.
Teiichi Murakami, et al., Synthesis Of 2-Formyladenoise Using Diethoxyacetonitrile As A Synthon, Heterocycles, vol. 16, No. 8, 1981.
Kiyoshi Omura, et al., Synthesis of 2-Phenylaminoadenosine From Imidazole Nucleosides, Chem. Pharm. Bull., 29 (7) 1870-1875, 1981.
Elliot Shaw, 5-Amino-4-Imidazolecarboxamide Riboside From Inosine. Ring-opeing Reactions Of Purine Nucleosides, Organic And Biological Chemistry, vol. 80, pp. 3899-3902, Aug. 5, 1958.
Prem C. Srivastava, et al., Synthesis of 5-Amino-1-(5-deoxy-.beta.-D-Ribofuranosyl) Imidazole-4-Carboxamide And Related 5'-Deoxyimidazole Ribonucleosides, Journal of Medicinal Chemistry, vol. 18, No. 12, pp. 1237-1240, 1975.
Jennifer A. Suggs, et al., Synthesis And Biodistribution Of p-Iodophenyl Analogues Of A Naturally Occuring Imidazole Ribonucleoside, J. Heterocyclic Chem., 25, 1331, Sep.-Oct. 1988.

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