Sulfur-substituted mevinic acid derivatives

Details Sulfur-substituted mevinic acid derivatives Sulfur-substituted mevinic acid derivatives

1991-12-20

1994-02-15

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514510, 560 1, 560 10, 560 80, 560 81, 560105, 560117, 560119, 560122, 560123, 560124, 560125, 560126, 560147, 560152, 560187, 560188, 560256, A61K 3135

Patent

active

052867463

ABSTRACT:
Antihypercholesterolemic activity is exhibited by compounds of the formula ##STR1## wherein: X is hydrogen, alkali metal or ammonium;

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patent: 4448979 (1984-05-01), Terahara et al.
patent: 4450171 (1984-05-01), Hoffman et al.
F. M. Singer et al.; "New Inhibitors of in vitro Conversion of Acetate and Mevalonate to Cholesterol", Proc. Soc. Exper. Biol. Med., 102, 370 (1959).
F. H. Hulcher, "Inhibition of Hepatic Cholesterol Biosynthesis by 3,5-Dihydroxy-3,4,4-trimethylvaleric Acid and its Site of Action", Arch. Biochem. Biophys., 146, 422 (1971).
A. G. Brown et al., "Crystal and Molecular Structure of Compactin, a New Antifungal Metabolite from Penicillium brevicompactum", J. Chem. Soc. Perkin I. 1165-1170 (1976).
U.S. patent application Ser. No. 724,272, Jul. 1991.

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