Derivatives of A-30912H nucleus

Details Derivatives of A-30912H nucleus Derivatives of A-30912H nucleus

1980-08-25

1981-10-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

042934915

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.4 is C.sub.1 -C.sub.6 alkyl and R.sup.1 is an N-alkanoyl amino acyl group of the formula ##STR2## wherein: W is a divalent aminoacycl radical of the formula ##STR3## wherein A is C.sub.1 -C.sub.10 alkylene or C.sub.5 -C.sub.6 cycloalkylene; ##STR4## wherein R.sup.3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indolemethyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl; ##STR5## wherein X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, mercapto, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl; ##STR6## wherein X.sup.1 is chloro, bromo, or iodo; ##STR7## wherein B is a divalent radical of the formula:--(CH.sub.2).sub.n --, wherein n is an integer from 1 to 3; --CH.dbd.CH--; ##STR8## and R.sup.2 is C.sub.1 -C.sub.17 alky or C.sub.2 -C.sub.17 alkenyl; have antifungal activity.

REFERENCES:
patent: 3150059 (1964-09-01), Kleizschmidt
patent: 3978210 (1976-08-01), Mizuno et al.
patent: 4024245 (1977-05-01), Hoehn et al.
patent: 4024246 (1977-05-01), Higgens et al.
patent: 4050989 (1977-09-01), Kuwana et al.
patent: 4173629 (1979-11-01), Dreyfuss et al.
Tetrahedron Letters No. 46, pp. 4147-4150, 1976.
Helvetica Chimica Acta-vol. 62, Fasc. 4 (1979) 1252-1266.
The Journal of Antibiotics 1976, 380-389, vol 29, No. 4.
The Journal of Antibiotics 1976, 1268-1274 vol. 29, No. 12.
The Journal of Antibiotics vol. 29, No. 12 1275-1280, 1976.
Helvetica Chimica Acta, vol. 57, Fasc. 8 (1974) 2459-2477.
The Journal of Antibiotics vol. 29, No. 12, 1339-1340, 1976.
Agr. Biolg. Chem., 37 (112), 2455-2463, 1973.
Agr. Biol. Chem., 37 (12), 2709-2717, 1973.
Agr. Biol. Chem., 38 (3), 521-529, 1974.
Agr. Biol. Chem. 38 (10), 1767-1777 (1974).
The Journal of Biochemistry, vol. 56, No. 4, 1964. 335-343.
The Journal of Antibiotics vol. 31, No. 4, 373-374, (1978).
The Journal of Antibiotics (1975) 764-769, vol. 28, No. 10.

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