GnRH Antagonists IV

Details GnRH Antagonists IV GnRH Antagonists IV

1984-05-21

1986-02-11

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125LH, 2601125R, C07C10352, A61K 3702

Patent

active

045699275

ABSTRACT:
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure:

REFERENCES:
patent: 4317815 (1982-03-01), Coy et al.
patent: 4341767 (1982-07-01), Nestor et al.
patent: 4444759 (1984-04-01), Rivier et al.
Coy et al., Endocrinology, vol. 110, No. 4, 1982, pp. 1445-1447.
Yabe et al., "Synthesis and Biological Activity of LH-RH Analogs Substituted by Alkyltryptophans at Position 3.sup.1)", Chem. Pharm. Bull., 27(8) 1907-1911, (1979).

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