Human induced tumor protein

Details Human induced tumor protein Human induced tumor protein

1996-08-16

1998-07-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 4352542, 536 231, 536 235, C12P 2100

Patent

active

057767327

ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a novel human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.

REFERENCES:
Accession No. N31858, Hillier et al. (1996) yx71c01.r1 Homo Sapiens cDNA clone 267168 5'.EST Database.
Accession No. Z44998, Auffray et al. (1994) H. Sapiens partial cDNA sequence; clone c-2ed08. EST Database.
Accession No. R12298, Hillier et al. (1995) yf48f11.r1 Homo sapiens cDNA clone 25383 5'. EST Database.
Lebel, M., et al., "Sequence analysis of a novel cDNA which is overexpressed in testicular tumors from polyomavirus large T-antigen transgenic mice" DNA Seq., 5:31-39 (1994).
Vielkind, U., "Genetic Control of Cell Differentiation in Platyfish-Swordtail Melanomas" J. Exp. Zool., 196:197-204 (1974).
Raza, A., et al., "Clinical and Prognostic Significance of In Vivo Differentiation in Acute Myeloid Leukemia"Amer. J. Hematology, 42:147-157 (1993).
Dakuor, J. et al., (GI 1293563), GenBank Sequence Database (Accession U49188), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, 07 Mar. 1996.
Pfeiffer, S.S.E., (GI 310100), GenBank Sequence Database (Accession L20319), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, 30 Jun. 1993.

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