Process for preparation of substituted pyridines

Details Process for preparation of substituted pyridines Process for preparation of substituted pyridines

1985-08-27

1989-04-25

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546310, C07D21102

Patent

active

048249548

ABSTRACT:
Disclosed herein is a novel process for the preparation of 4-amino-3,5-pyridinedicarboxylate derivatives by (a) reaction of an acetonediester with a primary amine to form an enamine, (b) reaction with a carboxylic acid anhydride or halide to form a 2-alkylcarbonyl-3-amino-2-pentenedicarboxylate, and (c) reaction with a halogenated alkylnitrile to form the pyridinedicarboxylate product. The product is useful as a herbicide or an intermediate in the formation of a herbicide.

REFERENCES:
Rappoport, Z. "The Chemistry of the Cyano Group" Interscience Publishers (1970) pp. 378-383.
House, H. O. "Modern Synthetic Methods" Benjamin Cummings Publishing Co. (1972) pp. 546-549, 570-573, 766-769.
Klingsberg, E. Pyridine and its Derivatives Pt. 1 (1960) p. 309.

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