Process for the preparation of pyrimidines

Details Process for the preparation of pyrimidines Process for the preparation of pyrimidines

1987-12-14

1989-04-25

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544321, C07D23947

Patent

active

048249491

ABSTRACT:
Process for the preparation of pyrimidines Pyrimidines of the formula I ##STR1## in which X and Y, independently of one another, denote oxygen or sulfur, R.sup.1 and R.sup.2, independently of one another, denote (C.sub.1 --C.sub.4) alkyl, (C.sub.1 --C.sub.4 -alkoxy)-C.sub.1 --C.sub.2 -alkyl or halo-C.sub.1 --C.sub.4 -alkyl, and R.sup.3 denotes C.sub.1 --C.sub.4 -alkyl, phenyl or phenoxy which may both be substituted by one, two or three radicals from the series comprising halogen, C.sub.1 --C.sub.4 -alkoxy and C.sub.1 --C.sub.4 -alkyl radicals, halo-C.sub.1 --C.sub.4 -alkyl or C.sub.1 --C.sub.4 -alkoxy, are obtained in a process in which propanediimidates of the formula II ##STR2## or salt thereof, are reacted with N-cyanoamides of the formula NC--NR.sup.4 --CO--R.sup.3 in which R.sup.4 denotes hydrogen or a cation, in an inert solvent. The compounds of the formula I are suitable as intermediates for the preparation of herbicidal sulfonylureas.

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Chem. Pharm. Bull., "Studies on Antitumor Substances. Reaction of N-Amidino-O-alkylisourea with Some Carboxylic Esters", Hayashi et al., vol. 16 (3), p. 474 (1968).
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