Process for 3-halo-1-carba(dethia)-3-cephem antibiotics

Details Process for 3-halo-1-carba(dethia)-3-cephem antibiotics Process for 3-halo-1-carba(dethia)-3-cephem antibiotics

1987-02-25

1988-10-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104

Patent

active

047788844

ABSTRACT:
7.beta.-Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxyli c acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.

REFERENCES:
patent: 4708956 (1987-11-01), Hirata et al.
Su et al., CA 94-209144k.
Kemp, CA 95-115374d.
Su et al., J. Org. Chem., 1981, 46(9), 1970-2.
Uyeo, S. and Ona, H., "Synthesis of 1-Carbacephem Derivatives", Chem. Pharm. Bull., 28 (5), 1563-1577, (1980).

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