Prodrugs based on phospholipid-nucleoside conjugates

Details Prodrugs based on phospholipid-nucleoside conjugates Prodrugs based on phospholipid-nucleoside conjugates

1982-02-03

1984-09-11

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1512, C07H 1700

Patent

active

044711131

ABSTRACT:
The invention relates to the production of a single diastereomeric form of a phospholipid araC conjugate as a prodrug.

REFERENCES:
patent: 4096324 (1978-06-01), Kelly et al.
patent: 4291024 (1981-09-01), Turcotte
MacCoss et al., "Synthesis and Biological Activity of Novel Nucleoside-Phholipid Prodrugs", Proced. 4th Int. Round Table, Nucleosides, Nucleotides and their Biol. Appl'ns Antwerp, 4-6, Feb., 1981, pp. 46-47.
Matsushita et al., Cancer Research 41, 2707-13, Jul. 1981.
MacCoss et al., Biochem. & Biophys. Res. Comm. 85 (2), Nov. 29, 1978, pp. 714-723.
Turcotte et al., Biochemica et Biophysica Acta, 619 (1980), pp. 604-618.

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