Method of inhibiting cataracts by topical application of a 2-sub

Details Method of inhibiting cataracts by topical application of a 2-sub Method of inhibiting cataracts by topical application of a 2-sub

1987-03-18

1988-10-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514912, A61K 3141

Patent

active

047788151

ABSTRACT:
A method of inhibiting cataract formation occasioned by the oxidative cross-linking of proteinaceous material in the lens fiber of the eye of a mammal comprising the topical administration of an effective antioxidant amount, to the eye of said mammal in need of the same, of a compound of the formula: ##STR1## wherein R is phenyl or phenyl substituted lower alkyl, the phenyl group of each being unsubstituted or substituted by halo, lower alkyl, lower alkoxy, trifluoromethyl, nitro, di-loweralkylamino, cyano, carboxy, methylenedioxy, loweralkoxycarbonyl, carboxyloweralkyl, or loweralkoxycarbonyl-lower alkyl, or R is cycloalkyl of 5 to 10 carbon atoms; and

REFERENCES:
patent: 4352799 (1982-10-01), Renson et al.
patent: 4397858 (1983-08-01), Welter et al.
patent: 4418069 (1983-11-01), Welter et al.
patent: 4454068 (1984-06-01), Welter et al.
patent: 4550168 (1985-10-01), Welter et al.
patent: 4711961 (1987-12-01), Welter et al.
Chem. Abst. 106:43,658v (1987)-Van Dyke et al.
Chem. Abst. 106:102,292w & 106:102293x (1987)-Welter et al.

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