Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1986-12-17
1988-10-18
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 68, 4351722, 43524027, 435810, 435948, 436 67, 436 87, 436548, 436808, 530387, 530388, 935 89, 935 93, 935 95, 935 96, 935 99, 935100, 935106, 935110, G01N 3353, G01N 33577, C12N 1500
Patent
active
047787520
ABSTRACT:
Epitope-specific reagents in the form of receptors that bind to hapten-modified proteins and do not bind to unmodified proteins, methods of their preparation and use, along with diagnostic systems for measuring the presence and amount of hapten-modified protein in an assayed sample are disclosed. In particular, monoclonal antibodies that bind reduced glycosylated proteins (for example, reductively glucosylated proteins including human plasma lipoproteins), but do not react with non-reduced glycosylated proteins, reduced non-glycosylated proteins or non-reduced non-glycosylated proteins are produced and utilized.
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Curtiss Linda K.
Witztum Joseph L.
Nucker Christine M.
Scripps Clinic and Research Foundation
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