Fused pyridine derivatives useful as angiotensin II antagonists

Details Fused pyridine derivatives useful as angiotensin II antagonists Fused pyridine derivatives useful as angiotensin II antagonists

1992-10-14

1994-12-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, A61K 3144, C07D47104

Patent

active

053730151

ABSTRACT:
The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z, G.sup.1, G.sup.2, G.sup.3 and G.sup.4 have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure.

REFERENCES:
patent: 4920131 (1990-04-01), Huang et al.
patent: 5028615 (1991-06-01), Huang et al.
patent: 5124335 (1992-06-01), Patchett et al.
patent: 5126344 (1992-06-01), Roberts et al.
patent: 5130318 (1992-07-01), Roberts et al.
patent: 5246944 (1993-09-01), Greenlee et al.
H. Gildemeister et al., "Neue 4-Chinolinol- und 5,6,7,8-Tetrahydro-4-chinoliol-abkommlinge mit biozider Wirkung", Liebigs Ann. Chem. 1982, 1656-1676.
P. Bellingham et al., "The Kinetics and Mechanism of Electrophilic Substitution of Heteoaromatic Compounds Part XV. Hydrogen Exchange of 3,5-Dimethylphenol and Heterocyclic Analogues", J. Chem. Soc. (B), 1968, pp. 866-873.
Ishibe et al., "Photoisomerization of 4-Pyridones to 2-Pyridones", Journal of the American Chemical Society, vol. 96, No. 4, Feb. 20, 1974, pp. 1152-1158.
Makabe et al., "A Convenient Synthesis of 1,4-Dihydro-4-Oxonicotinic Acid Derivatives", Heterocycles, vol. 13, 1979, pp. 239-246.
Hackler et al., "The Synthesis of 5-Amino-3-t-butylisothiazole and 3-Amino-5-butylisothiazole", J. Heterocyclic Chem. 26, 1575 (1989), pp. 1575-1578.
Veronese et al., "Tin (VI) Chloride-Promoted Reactions of .beta.-Dicarbonyl Compounds with Nitriles. Synthesis of Aminopyridines and Aminoquinolenes". Tetrahedron Letters, vol. 31, No. 24, pp. 3485-3488, 1990.
Ziegler et al., "Synthesen Von Heterocyclen, 120, Mitt: 2,6-Dimethyl-4-pyridone dureh Reaktion von Enaminen Mit Diketen", Monatshefte fur Chemie 100, 132-135 (1969).

Affiliated with

Also associated with

Rating

Fused pyridine derivatives useful as angiotensin II antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused pyridine derivatives useful as angiotensin II antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused pyridine derivatives useful as angiotensin II antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1193657