Certain (arylsulfonamido- and imidazolyl-)-substituted carboxyli

Details Certain (arylsulfonamido- and imidazolyl-)-substituted carboxyli Certain (arylsulfonamido- and imidazolyl-)-substituted carboxyli

1990-12-26

1992-10-06

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514399, 548252, 548253, 5483401, A61K 31415, C07D23361, C07D40306, C07D40612

Patent

active

051532140

ABSTRACT:
The present invention is concerned with compounds of formula I ##STR1## wherein A, B, M, R, Ar and Het are as defined in the specification, pharmaceutically acceptable ester and amide derivatives thereof; N-oxides thereof, tetrazole derivatives thereof, and salts thereof. These compounds have valuable pharmacological activities, especially as inhibitors of thromboxane synthetase and as receptor antagonists of thromboxane A.sub.2 and prostaglandin H.sub.2.

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