Process for the isolation and purification of monosialogangliosi

Details Process for the isolation and purification of monosialogangliosi Process for the isolation and purification of monosialogangliosi

1992-02-12

1992-10-06

Sever, Frank

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 88, 514558, 514885, A61K 3722

Patent

active

051529980

ABSTRACT:
By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GMl) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GMl with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa-cyclodextrin.

REFERENCES:
patent: 4710490 (1987-12-01), Catsimpoolas et al.

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