Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-07-29
1990-09-11
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546256, 546280, 424114, C07D41704, A01N 4378
Patent
active
049563742
ABSTRACT:
Novel antifungal antibiotic compounds have the structural formula ##STR1## A preferred compound where R is 4-hydroxypentyl is denoted BU-3557B.sub.2. A complex of said compounds is produced by fermenting a culture of Sacchrothrix aerocolonigenes strain N806-4 (ATCC 53712). The complex is recovered by adsorption on nonionic porous polymer resin adsorbent and individual component compounds exhibit in vitro activity against fungi and Gram-positive bacteria and BU-3557B.sub.2 demonstrates in vitro antiprotazoal activity. BU-3557B.sub.2 demonstrates in vivo activity against C. albicans vaginal infection and BU-3557A.sub.3 (where R is 1,5-dihydroxy-5,5-dimethylpentyl) demonstrates in vivo activity against C. albicans systemic infection.
REFERENCES:
patent: 4798838 (1989-01-01), Kojima et al.
patent: 4849434 (1989-07-01), Enomoto et al.
patent: 4898947 (1990-02-01), Meguro et al.
Ando Shigeyuki
Konishi Masataka
Miyaki Takeo
Nishio Maki
Oki Toshikazu
Bristol-Myers Company
Carnahan Robert E.
Rotman Alan L.
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