Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1982-04-21
1985-06-11
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514321, 514331, 514332, 514357, 514428, 514649, 514212, 514318, 564340, 564341, 564346, 564353, 564354, 260239B, 260239BA, 546194, 546197, 546235, 546261, 546264, 546267, 546273, 546281, 546333, 548526, 548569, 549435, 549444, C07D21106, C07D29510, A61K 31445, A61K 3155
Patent
active
045229430
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.
REFERENCES:
patent: 4062863 (1977-12-01), Ganellin et al.
patent: 4233302 (1980-11-01), Martin-Smith et al.
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4318913 (1982-03-01), Clitherow et al.
patent: 4323566 (1982-04-01), Clitherow et al.
Brittain, Tips, (Nov. 1981), pp. 310-313.
Algieri Aldo A.
Crenshaw Ronnie R.
Bristol-Myers Company
Daus Donald G.
Lloyd Richard R.
Teoli, Jr. William A.
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