Diuretic/antihypertensive compositions

Details Diuretic/antihypertensive compositions Diuretic/antihypertensive compositions

1982-10-14

1985-06-11

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Para-n-benzene - sulfoxy-n containing doai, and said benzene...

514259, A61K 31635

Patent

active

045228183

ABSTRACT:
A combination tablet containing metolazone and triamterene is useful in diuretic therapy and the treatment of hypertension. The composition is advantageous in the prevention of hypokalemia, a common side effect of diuretic therapy and possesses enhanced dissolution properties. Proper selection of the excipient formulation permits preparation of the tablets by direct compression.

REFERENCES:
patent: 3081230 (1963-03-01), Weinstock et al.
patent: 3360518 (1967-12-01), Shetty
Matochik, T., Paper Submitted for Internship Research Credit at Pennwalt Corp.: The In Vivo, In Vitro Analysis of a Fixed Combination Diuretic by Reversed Phase High Pressure Liquid Chromatography, Sent to Rochester Institute of Technology 1979; on File in RIT Chemistry Library.
Di-Tab Bulletin, Stauffer Chemical Co., Aug. 1981.
Hohenegger, M. et al., Int. J. Clin. Pharmacol. 1976, 13(4), 298-303.
Onesti G., Drug Therapy, 66-78 (6/1975).
Zeller J., Current Therapeutic Research, 29(4), 45-1 to 45-8 (1981).
Hollifield J., et al., In Systemic Effects of Antihypertensive Agents (Sambhi M.-Editor), Symposia Specialists, 1976, pp. 131-155.
Chemical Abstracts, 85: 104041k (1976) [Hohenegger, M., et al., Int. J. Clin. Pharmacol. Biopharm. 1976, 13(4), 298-303].

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