Method of preparing 2-fluoro-17.beta.-estradiol

Details Method of preparing 2-fluoro-17.beta.-estradiol Method of preparing 2-fluoro-17.beta.-estradiol

1983-12-22

1985-06-11

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 100

Patent

active

045227586

ABSTRACT:
2-Fluoro-17.beta.-estradiol is synthesized by mercurating a 17.beta.-estradiol diacylate or dietherate at C-2, replacing the mercury group with fluorine and then cleaving the acyl or ether protecting groups.

REFERENCES:
J.C.S. Chem. Comm. (1981) 217, p. 1157, article by Santaniello.
Liehr, Molecular Pharmacology, 23, 278 (1983).
Utne et al., J. Org. Chem. 33, 2469 (1968).
Neeman et al., J. Chem. Soc. (Perkin Trans. 1) 2300 (1972).
Palmer et al., J. Labelled Compds., 16, 14 (1979).
Eakins et al., Int. J. App. Rad. & Iso., 30, 695 (1979).
Heiman et al., J. Med. Chem., 23, 994 (1980).
Goswami et al., id, 1002.
Ng et al., J. Org. Chem., 46, 2520 (1981).
Santaniello, J.C.S. Chem. Comm., 217, 1157 (1981).
Njar et al., J. Org. Chem., 48, 1007 (1983).
Rozen et al., J.C.S. Chem. Comm., 443 (1981).
Shiue, J. Nucl. Med., 23, 899 (1982).
Mantescu et al., Radiopharm. & Labelled Compds., 395 (1973).

Affiliated with

Also associated with

Rating

Method of preparing 2-fluoro-17.beta.-estradiol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of preparing 2-fluoro-17.beta.-estradiol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preparing 2-fluoro-17.beta.-estradiol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1182152