Benzopyranopyridines as antiglaucoma agents

Details Benzopyranopyridines as antiglaucoma agents Benzopyranopyridines as antiglaucoma agents

1980-01-17

1981-01-27

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424244, 424263, 424272, 424273R, A61K 31435, A61K 3133, A61K 3144, A61K 3142

Patent

active

042475570

ABSTRACT:
A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in the C ring, X is CH.sub.2, S, ##STR2## or NR.sub.4 is H, loweralkyl, loweralkenyl, loweralkynyl or loweralkanoyl; n is an integer of 0 to 3; m is an integer of 0 to 3, or the C ring is a quinuclidine ring ##STR3## each R.sub.1 is loweralkyl, and when taken together, the substituents R.sub.1 R.sub.1 form oxygen; R.sub.2 is a C.sub.1 -C.sub.20 straight or branched chain alkyl, cycloalkyl, or ##STR4## wherein Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms, and each R.sub.5, R.sub.6 and R.sub.7 are the same or different members of the group consisting of H, halo or loweralkyl; R.sub.3 is H or ##STR5## wherein Y' is a straight or branched chain alkylene group having 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH.sub.2, O, S or NR.sub.9 where R.sub.9 is H or loweralkyl, with the provision that when Z is O, S or NR.sub.9, the sum of a and b is 3 or 4, and R.sub.8 is H or loweralkyl; and the pharmaceutically acceptable salts thereof.

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