Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1994-08-26
1996-12-24
Geist, Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514558, 514559, 514563, 514725, A61K 3119
Patent
active
055873960
ABSTRACT:
New topically applied treatments for cellulite are shown by comparative data to effect structural improvements in cellulite-afflicted thigh area tissues including skin-thickening, thigh-firming and thigh-reduction. The disclosed treatments disrupt the skin's water barrier and elevate trans-epidermal water loss (TEWL) for extended periods of weeks or months and include methods of mechanical or solvent action, for example, tape stripping, or acetone washes. Preferred treatments use creams with active ingredients such as lactic acid to elevate TEWL, a retinoid, preferably vitamin A palmitate to disrupt barrier rebuilding and prolong elevation of TEWL levels, and a cerebroside to inhibit lipid synthesis and intensify the TEWL elevation. Diuretics, for immediate esthetic improvements, anti-irritants and anti-oxidants for irritation control are optional ingredients.
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J. Pinnagoda, et al., "Measurement of the Transepidermal Water Loss," Chapter 9.1, (1995) pp. 173-178.
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Proksch et al. "Barrier Function regulates epidermal lipid and DNA synthesis" British Journal of Dermatology (1993) 128, 473-482.
Carr Deborah D.
Geist Gary
Mary Kay Inc.
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