DNA encoding asparaginyl tRNA synthetase from staphylococcus aur

Details DNA encoding asparaginyl tRNA synthetase from staphylococcus aur DNA encoding asparaginyl tRNA synthetase from staphylococcus aur

1997-01-17

1998-08-04

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4353201, 4352523, 43525411, 435325, 536 232, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057892172

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Kim et al. (1996) Lactobacillus bulgaricus Asparagine Synthetase and Asparaginyl-tRNA Synthetase: Coregulation by Transcription Antitermination? J. Bacteriol. 178(8): 2459-2461.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparagiinyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression inEscherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Bork, et al., "Exploring the Mycoplasma capricolum Genome: a minimal cell reveals its physiology", Molecular Microbiology, 16(5), pp. 955-967 (1995).
Bruand, et al., Nucleotide sequence of the Bacillus subtilis dnaD gene, Microbiology, 141, pp. 321-322 (1995).
Kazura, et al., "Differential Recognition of a Protective Filarial Antigenn by Antibodies from Humans with Bancroftian Filariasis", J. Clin. Invest., 77, pp. 1985-1992 (1986).

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