Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-08-04
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436 94, 530334, 536 253, C12Q 168, C12M 134, C07H 1900, C07K 100
Patent
active
057891621
ABSTRACT:
A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
REFERENCES:
patent: 4587044 (1986-05-01), Miller et al.
patent: 4631211 (1986-12-01), Houoghten
patent: 4671941 (1987-06-01), Niina et al.
patent: 4701304 (1987-10-01), Horn et al.
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4755558 (1988-07-01), Kalbag
patent: 4762881 (1988-08-01), Kauer
patent: 4780423 (1988-10-01), Bluestein
patent: 4794150 (1988-12-01), Steel
patent: 4818681 (1989-04-01), Dattagupta
patent: 4833092 (1989-05-01), Geysen
patent: 4855225 (1989-08-01), Fung et al.
patent: 4882269 (1989-11-01), Schneider et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5264563 (1993-11-01), Huse
patent: 5324483 (1994-06-01), Cody et al.
patent: 5510240 (1996-04-01), Lam et al.
patent: 5708153 (1998-01-01), Dower et al.
Advances in Analytical Chemisrty and Instrumentation, Charles N. Reilley, Ed., John Wiley & Sons, Inc., 1964, pp. 56-59.
Amato, 1992, Science, 257:330-331 Speeding up a chemical game of chance.
Arnold et al., 15 Mar. 1991, Optics Letters 16(6):420-422 Room-temperature microparticle-based persistent spectral hole burning memory.
Baldwin et al., 1990, Tetrahedron 46(19):6879-6884 New Photolabile phosphate protecting groups.
Barr et al., 1986, BioTechniques 4(5):428-432 7-Deaza-2'-deoxyguanosine-5'-triphosphate: Enhanced resolution in M13 dideoxy sequencing.
Bashkin et al., 1991, J. Org. Chem. 56:3168-3176 Synthesis and characterization of oligonucleotide peptides.
Borchardt et al., 1994, J. Am. Chem. Soc. 116:373-374 Synthetic receptor binding elucidated with an encoded combinatorial library.
Brenner et al., 1992, Proc. Natl. Acad. Sci. USA 89:5381-5383 Encoded combinatorial chemistry.
Crick et al., 1957, Proc. Natl. Acad. Sci. USA 43:416-421 Codes without commas.
Cwirla et al., 1990, Proc. Natl. Acad. Sci. USA 87:6378-6382 Peptides on phage: A vast library of peptides for identifying ligands.
Eritja et al., 1991, Tetrahedron 47(24):4113-4120 Synthesis of defined peptide-oligonucleotide hybrids containing a nuclear transport signal sequence.
Farrall et al., 1976, J. Org. Chem. 41(24):3877-3882 Bromination and lithiation: Two important steps in the functionalization of polystyrene resins.
Fodor et al., 1991, Science 251:767-773 Light-directed, spatially addressable parallel chemical synthesis.
Frank and Doring, 1988, Tetrahedron 44(19):6031-6040. Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports.
Frank et al., 1983, Nucl. Acids. Res. 11(13):4365-4377 A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: Segmental solid supports.
Frank et al., 1990, Peptides (Giralt & Andreu. eds., ESCOM Science Pub.), pp. 151-152 Facile and rapid `spot-synthesis`of large numbers of peptides on membrane sheets.
Furka et al., 10-15 Jul. 1988, 14th Intl. Congress of Biochemistry, Prague, Czechoslovakia, Abstract No. FR:013 Proteins and nucleic acids in three dimensions: Cornucopia of peptides by synthesis.
Furka et al., 15-19 Aug. 1988, Xth Intl. Symp. on Medicinal Chem., Budapest, Hungary, Abstract No. P-168, p. 288 More peptides by less labour.
Furka et al., 1991, Int. J. Peptide Protein Res., 37:487-493 General method for rapid synthesis of multicomponent peptide mixtures.
Geysen et al., 1987, J. Immunol. Meth., 102:259-274 Strategies for epitope analysis using peptide synthesis.
Geysen et al., 1984, Proc. Natl. Acad. Sci. USA, 81:3998-4002 Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.
Gordon et al., 1994, J. Med. Chem., 37(10):1385-1401 Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
Haralambidis et al., 1990, Nuc. Acids Res. 18(3):493-505 The synthesis of polyamide-oligonucleotide conjugate molecules.
Hayakawa et al., 1990, J. Am. Chem. Soc. 112:1691-1696 The allylic protection method in solid-phase oligonucleotide synthesis: An efficient preparation of solid-anchored DNA Oligomers.
Hodgson, 1992, Bio/Technology 10:973-974 Receptor screening and the search for new pharmaceuticals.
Houghten et al., 1991, Nature 354:84-86 Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.
Houghten, 1985, Proc. Natl. Acad. Sci. USA 82:5131-5135 General method for rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids.
Juby et al., 1991, Tetrahedron Letters 32(7):879-882 Facile preparation of 3' oligonucleotide-peptide conjugates.
Kaiser et al., 1989, Science 243:187-192 Peptide and protein synthesis by segment synthesis-condensation.
Kerr et al., 1993, J. Am Chem Soc., 115:2529-2531 Encoded combinatorial peptide libraries containing non-natural amino acids.
Lam et al., 1991, 12th Amer. Pep. Symp., Abstract LW3 Rapid selection and structure determination of acceptor binding ligands from a large synthetic peptide library.
Lam et al., 1992, Pept.: Chem. Bio. Proc. Am. Pept. Symp. 12th, pp. 492-495 The selectide process: Rapid generation of large synthetic peptide libraries linked to identification and structure determination of acceptor-binding ligands.
Lam et al., 1991, Nature 354:82-84 A new type of synthetic peptide library for indentifying ligand-binding activity.
Mathur et al., 1980, Polymers as Aids in Organic Chemistry, Academic Press, New York, Ch. 9-12:138-197.
Needels et al., 1993, Proc. Natl. Acad. Sci. USA, 90:10700-10704 Generation and screening of an oligonucleotide-encoded synthetic peptide library.
Nikolaiev et al., 1993, Peptide Research, 6(3):161-170 Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid phase supports.
Ohlmeyer et al., 1993, Proc. Natl. Acad. Sci. USA, 90:10922-10926 Complex synthetic chemical libraries indexed with molecular tags.
Tjoeng et al., 1990, Int. J. Pept. Protein Res. 35:141-146 Multiple peptide synthesis using a single support (MPS3).
Van Brundt, Nov. 16, 1993, BioWorld Today pp. 3-5 Affymax creates new large-scale drug screen.
Van der Zee et al., 1989, Eur. J. Immunol. 19:43-48 Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides.
Barrett Ronald W.
Dower William J.
Gallop Mark A.
Affymax Technologies N.V.
Horlick Kenneth R.
Kaster Kevin R.
Stevens Lauren L.
LandOfFree
Methods of synthesizing diverse collections of oligomers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of synthesizing diverse collections of oligomers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of synthesizing diverse collections of oligomers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1175585