Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-07-30
2000-04-11
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424484, 424486, 4284022, 264 41, 264 43, A61K 9127, A61K 926
Patent
active
060485469
ABSTRACT:
A method for preparing encapsulated lipid-bilayer materials in a silica matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and allowing the mixture to gel to form the encapsulated lipid-bilayer material. The mild processing conditions allow quantitative entrapment of pre-formed lipid-bilayer materials without modification to the material's spectral characteristics. The method allows for the immobilization of lipid membranes to surfaces. The encapsulated lipid-bilayer materials perform as sensitive optical sensors for the detection of analytes such as heavy metal ions and can be used as drug delivery systems and as separation devices.
REFERENCES:
patent: 4740375 (1988-04-01), Geho et al.
patent: 4921757 (1990-05-01), Wheatley et al.
patent: 5200334 (1993-04-01), Dunn et al.
patent: 5300564 (1994-04-01), Avnir et al.
patent: 5376379 (1994-12-01), Fabre et al.
patent: 5616790 (1997-04-01), Arnold et al.
D. Y. Sasaki, D. R. Shnek, D. W. Pack, and Frances H. Arnold, Metal-Induced Dispersion of Lipid Aggregates: A simple, Selective, and Sensitive Fluorescent Metal Ion Sensor, Chem. Int. Ed. Engl. 1995, 34,905.
D. R. Shnek, D. W. Pack, D. Y. Sasaki, and F. H. Arnold, Specific Protein Attachment to Artificial membranes via Coordination to Lipid-Bound Copper(II), 1994 American Chemical Society.
Lisa M. Ellerby, Clinton R. Nishita, Fumito Nishida, Stacey A. Yamanaka, Bruce Dunn, Joan Selverstone Valentine, Jeffrey I. Zink, Encapsulatin of Proteins in Transparent Porous Silicate Glasses Prepared by the Sol-Gel Method, Reports, Feb. 28, 1992, pp. 1113-1115.
Sabina Merlo and Paul Yager, Optical Method for Monitoring the Concentration of General Anesthetics and Other Small Organic Molecules. An Example of Phase Transition Sensing, 1990 American Chemical Society, vol. 62, pp. 2728-2735.
Smadar Cohen, M. Carmen Bano, Karyn B. Visscher, Marie Chow, Harry R. Allcock, and Robert Langer, Ionically Cross-Linkable Polyphosphazene: A Novel Polymer to Microencapsulation, J. Am. Chem. Soc., 1990, vol. 112, pp. 7832-7883.
G. Carturan, R. Campostrini, S. Dire, V. Scardi and E. De Alteriis, Inorganic Gels for Immobilizatin of Biocatalysis: Inclusion of Invertase-active Whole Cells of Yeast (Saccharomyces cerevisiae) into Thin Layers of SiO.sub.2 Gel Deposited on Glass Sheets, Journal of Molecular Catalysis Letter, 1989, vol. 57, pp. L13-L16.
Anke Reichert, Jon O. Nagy, Wayne Spevak, and Deborah Charych, Polydiacetylen Liposomes Functionalized with Sialic Acid Bind and Colorimetrically Detect Influenza Virus, J. Am. Chem. Soc. 1995, vol. 177, pp. 829-830.
Noga Yerushalmi and Rimona Margalit, Bioadhesive, Collagen-modified Liposomes: Molecular and Cellular Level Studies on the Kinetics of Drug Release and on Binding to Cell Monolayers, Biochem. Biophys. Acta, 1994, vol. 1189, pp. 13-20.
Dana V. Devine, Kenneth Wong, Katherine Serrano, Arcadio Chonn, and Pieter R. Cullis, Liposome-complement Interactions in Rat Serum: Implications for Liposome Survival Studies, Biochim. Biophys. Acta, 1994, vol. 1191, pp. 43-45.
Danilo D. Lasic, Sterically Stabilized Vesicles, Agnew. Chem., Int. Ed. Engl., 1994, vol. 33, pp. 1685-1698.
Hanlan Liu, Shaowei Ong, Louis Glunz, and Charles Pidgeon, Predicting Drug-Membrane Interactions by HPLC: Structural Requirements of Chromatographic Surfaces, Anal. Chem, 1995, vol. 67, pp. 3550-3557.
Joel M. Schnur, Lipid Tubules: A Paradigm for Molecularly Engineered Structures, Science, 1993, vol. 262, pp. 1669-1676.
T. Kunitake, Synthetic Bilayer Membranes: Molecular Design, Self-Organization, and Application, Angew. Chem., Int. Ed. Engl., 1992, 31, 709.
Per Lundahl, Qing Yang, Eva Greijer, and Maria Sandberg, Immobilization of Liposomes in Gel Beads, 2.sup.nd ed. CRC Press, 1993, vol. 1, 343-61.
Charles Pidgeon and U.V. Venkataram, Immobilized Artificial Membrane Chromatography: Supports Composed of Membrane Lipids, Anal. Biochem., 1989, 176, 36.
R.C. Hresko, I.P. Sugar, Y. Barenholz, and T.E. Thompson, Lateral Distribution of a Pyrene-labeled Phosphatidylcholine in Phosphatidylcholine Bilayers: Fluorescence Phase and Modulation Study, Biochemistry, 1986, 25, 3813-3823.
V. Gabrijelcic and M. Sentjurc, Influence of Hydrogels on Liposome Stability and on the Transport of Liposome Entrapped Substances into the Skin, Int. J. of Pharmaceutics, 1995, 119, 207-212.
C.J. Brinker, K.D., Keefer, D.W. Schaefer, and C.S. Ashley, Sol-gel transition in Simple Silicates, J. Non-Crystalline Solids, 1982, 48, 47-64.
A.L. Weiner, S.S. Carpenter-Green, E.C. Soehngen, R.P. Lenk, and M.C. Popescu, Lipsome-Collagen Gel matrix: A Novel Sustained Drug Delivery System, J. of Pharmaceutical Sciences, 1985, 74(9), 922-925.
Loy Douglas A.
Sasaki Darryl Y.
Yamanaka Stacey A.
Kishore Gollamudi S.
Klavetter Elmer A.
Sandia Corporation
LandOfFree
Immobilized lipid-bilayer materials does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Immobilized lipid-bilayer materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immobilized lipid-bilayer materials will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1174606