Antibody which is directed against and inhibits collagen binding

Details Antibody which is directed against and inhibits collagen binding Antibody which is directed against and inhibits collagen binding

1995-02-17

1998-08-04

Saunders, David

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241541, 4241731, 4241781, 4241831, A61K 39395

Patent

active

057889660

ABSTRACT:
The present invention provides methods of treating a subject suffering from a disorder associated with elevated levels of VLA-1 which comprises administering to the subject a therapeutically effective amount of an antibody which specifically forms a complex with VLA-1, inhibits collagen binding to VLA-1, and is directed to the epitope to which antibody 1B3.1 (ATCC No. HB10536) is directed and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5045451 (1991-09-01), Uhr et al.
P.A. Ward et al, Therapeutic Immunology, 1, 165-171, 1994.

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