Insulin sensitivity with angiotensin II receptor blocking imidaz

Details Insulin sensitivity with angiotensin II receptor blocking imidaz Insulin sensitivity with angiotensin II receptor blocking imidaz

1998-08-03

1999-10-05

Cooney, Jr., John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514359, 514385, 514396, 514397, A01N 4338

Patent

active

059625007

ABSTRACT:
This invention relates to a novel method of using an Angiotensin II antagonist for the improvement of insulin sensitivity alone or in conjunction with the treatment of hypertension. Angiotensin II antagonists such as the class of substituted imidazoles represented by formula I: ##STR1## and specifically by Losartan, yl)imidazole potassium salt.

REFERENCES:
patent: 5138069 (1992-08-01), Carini et al.
patent: 5264447 (1993-11-01), Ohtawa
patent: 5266583 (1993-11-01), Ohtawa
A. Moan et al.; "Agiotensin II (AII) Receptor Antagonism with Losartan Increases Insulin Sensitivity and Decreases Sympathetic Nervous System Activity in Essential Hypertension"Inter. Soc. Hypertension, (1994).
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A. Moan,et al., "Hypertension Therapy And Risk Of Coronary Heart Disease: How Do Antihypertensivies Affect Metabolic Factors?", Cardiology, vol. 86, pp. 89-93 (1995).
A. Moan, et al., "Angiotension II (A-II) Receptor Antagonism With Losartan Increases Insulin Sensitivity And Decreases Sympathetic Nervous System (SNS) Activity In Essential Hypertension", Int'l. Soc. Of Hypertension, pp. 21-25 (1994).
O. Iimura, et al., STN International File Biosis., STN ACC. No. 94:417516 Nineth Scientific Meeting of the Am. Society Hypertension, May 11-14, (1994), Am. J. of Hypertension 7 (4 part 2), (1994).
H. Tomiyama, et al., "Kinins Contribute to the Improvement of Insulin Sensitivity During Treatment With Angiotensin Converting Enzyme Inhibitor", Hypertension, vol. 23(4), pp. 450-455, (1994).
G. Bonner, "Hemmung des Renin-Angiotensin-Systems als Antihypertensives Prinzip", Munch. Med. Wschr., vol. 136(47), pp. 727-730, (1994).
K. Shimamoto, et al., "Effects of an Angiotensin II Receptor Antagonist, TCV-116, on Insulin Sensitivity in Fructose-Fed Rats", Blood Pressure, vol. 3(5), pp. 113-116, (1994).
H. Tomiyama, et al., "Role of Kinins in Different Responses of Insulin Sensitivity by Converting Enzyme Inhibitor, Angiotensin II Antagonist and Alpha 1-Blocker", Hypertension, vol. 20(3), p. 411, (1992).

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